BIOGRAPHICAL SKETCH

Provide the following information for the key personnel in the order listed for Form Page 2.

Follow the sample format for each person. DO NOT EXCEED FOUR PAGES.

 

NAME

 

Karin, Michael

POSITION TITLE

 

Professor of Pharmacology

 

EDUCATION/TRAINING  (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)

INSTITUTION AND LOCATION

DEGREE

(if applicable)

YEAR(s)

FIELD OF STUDY

Tel Aviv University, Tel Aviv, Israel

B.Sc.

1975

Biology

University of California, Los Angeles, CA

Ph.D.

1979

Molecular Biology

Fox Chase Inst. for Cancer Research, Phila., PA

Postdoc

1979-1980

Molecular Biology

 

A. Positions and Honors.

 

Research and Professional Experience: 1975-79 Grad. Student, Molecular Biology Institute, UCLA. Mentor: Dr. Harvey Herschman. 1979-80 Postdoc. Fellow, Fox Chase Inst. for Cancer Research., Philadelphia.  Mentor: Dr. Beatrice Mintz; 1980-82 Postdoc. Fellow, Dept. of Med. and Biochem., Univ. of Calif., San Francisco. Mentor: Dr. John Baxter; 1982-85 Asst. Professor of Microbiology, School of Med., USC; 1986-89 Assoc. Professor, Depts of Medicine and Pharmacology, Univ. of Calif., San Diego; 1989-Pres. Professor, Dept. of Pharmacology., Univ. of Calif., San Diego.

 

Honors: Magna Cum Laude, Tel Aviv Univ., 1975; Best Student Presentation , 22nd Symposium,Calif. Branch of the Tissue Culture Assoc., 1978; Senior Postdoc. Fellowship, American Cancer Soc., Calif. Div.,1981; Searle Scholars Award, 1984-1987; Tagnon Lectureship from EORTC, 1987; Oppenheimer Award for Excellence in Research, Endocrine Soc., 1990; Keynote Lecturer, Annual Mtg of Japan. Soc. for Endocrinology, 1990; Distinguished Lecturer, Baylor College of Med., 1990; Univ. of Calif. Chancellor's Associates Award for Excellence in Res., 1991; ICI Lecturer, Annual Mtg. of British Society for Developmental Biology, 1991; Distinguished Lecturer, U. Mass. Med. Center 1991; Faculty Distinguished Lecture, UCSD School of Med. 1993; Merck-Frosst Distin. Lectureship, Univ. of Alberta, 1994; The Herman Beerman Lecturer, Society for Investigative Dermatology, 1997.  MERIT Award from the National Institute of Environmental Health Sciences, 1998. Frank and Else Schilling-American Cancer Society Research Professor, 1999-2004; Plenary speaker at 6th UIUBMB Seoul Conf. Oct. 1999; ISI rated 1st worldwide for most cited molecular biology and genetic research papers, 2000; The Sheldon C. Siegel Lectureship, AAAAI, 2000; Dean’s Lecture, Mt. Sinai Medical School, 2000; Findling Lecture, Mayo Clinic, 2000; C.E.R.I.E.S. Research Award for Physiology or Biology of the Skin, 2000; Honorary Member, Japanese Biochemical Society, 2000; Neil C. Moran Lecture, Emory University 2001; Sandler Award in Asthma Research, 2001; Distinguished Lecturer, Baylor College of Medicine, 2002; 2003 Grossman Lecture, Amer. Gastroenterology Association; ranked 12th among the world’s most cited scientists in Science Watch, 2003.

 

Selected peer-reviewed publications (in chronological order, from more than 235 research papers)

 

- Dérijard, B., Hibi, M., Wu, I-H., Barrett, T., Su, B., Deng, T., Karin, M. and Davis, R.J. (1994) JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 76:1025-1037.

- Su, B., Jacinto, E., Hibi, M., Kallunki, T., Karin, M. and Ben-Neriah, Y. (1994) JNK is involved in signal integration during costimulation of T lymphocytes. Cell 77:727-736.

- Caelles, C., Helmberg, A. and Karin, M. (1994) p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes. Nature 370:220-223.

- Minden, A., Lin, A., McMahon, M., Lange-Carter, C., Dérijard, B, Davis, R.J., Johnson, G.L. and Karin, M. (1994) Differential activation of ERK and JNK MAP kinases by Raf-1 and MEKK.  Science 266:1719-1723.

- Lin, A., Minden, A., Martinetto, H., Claret, F.X., Lange-Carter, C., Mercurio, F., Johnson, G.L. & Karin, M. (1995) Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2. Science 268:286-290.

- Minden, A.J., Lin, A., Claret, F.X., Abo, A. and Karin, M. (1995) Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs.  Cell 81:1147-1157.

- Kallunki, T., Deng, T., Hibi, M. and Karin, M. (1996) c-Jun can recruit JNK to phosphorylate dimerization partners via specific docking interactions. Cell, 87:929-939.

- Liu, Z-G., Hsu, H., Goeddel, D.V. and Karin, M. (1996) Dissection of TNF receptor 1 effector functions: JNK  activation is not linked to apoptosis, while NF-kB activation prevents cell death. Cell, 87:565-576.

- DiDonato, J.A., Hayakawa, M., Rothwarf, D.M., Zandi, E. and Karin, M. (1997) A cytokine-responsive IkB kinase that activates the transcription factor NF-kB. Nature, 388:548-554.

- Zandi, E., Rothwarf, D.M., Delhase, M., Hayakawa, M., Karin, M. (1997) The IkB kinase complex (IKK) contains two kinase subunits, IKKa and IKKb, necessary for IkB phosphorylation & NF-kB activation.   Cell 91:243-252.

- Chen, C-Y, Del Gatto-Konczak, F., Wu, Z., Karin, M. (1998) Stabilization of Interleukin-2 mRNA by the c-Jun NH2-terminal kinase pathway. Science 280:1945-1949.

- Rothwarf, D.M., Zandi, E., Natoli, G., Karin, M. (1998).  IKKg is an essential regulatory subunit of the IkB kinase complex. Nature 395:297-300.

- Zandi, E., Chen, Y., Karin, M. (1998). Direct phosphorylation of IkB by IKKa and IKKb: Discrimination between free and NF-kB-bound substrate.  Science 281:1360-1363.

- Delhase, M., Hayakawa, M., Chen, Y. and Karin, M. (1999) Positive and negative regulation of IkB kinase activity through IKKb subunit phosphorylation.  Science 284:309-313.

- Hu, Y., Baud, V., Delhase, M., Zhang, P., Deerinck, T., Ellisman, M., Johnson, R. and Karin, M. (1999) Abnormal morphogenesis but intact IKK activation in mice lacking the IKKa subunit of the IkB kinase.  Science 284:316-320.

- Shaulian, E., Schreiber, M., Piu, F., Beeche, M., Wagner, E.F. and Karin, M. (2000) The mammalian UV response: c-Jun induction is required for exit from p53-imposed growth arrest. Cell. 103:897-907.

- Senftleben, U., Cao, Y., Xiao, G., Greten, F., Krahn, G., Bonizzi, G., Chen, Y., Hu, Y., Fong, A., Sun, S., and Karin, M. (2001) Activation by IKKa of a Second, Evolutionary Conserved, NF-kB Signaling Pathway. Science 293: 1495-1499.

- Hu, Y., Baud, V., Oga, T. Kim, K., Yoshida, K, and Karin, M. (2001) IKKa controls formation of the epidermis independently of NF-kB via a differentiation inducing factor. Nature 410:710-714.

- Cao, Y., Bonizzi, G., Seagroves, T., Greten, F., Johnson, R., Schmidt, E., Karin, M. (2001) IKKa Provides an Essential Link Between RANK Signaling and Cyclin D1 Expression During Mammary Gland Development. Cell 107:763-775.

- Chen, C-Y., Gherzi, R., Ong, S-E., Chan, E.L., Raijmakers, R., Pruijn, G.J.M., Stoecklin, G., Moroni, C., Mann, M., Karin, M. (2001) AU-binding Proteins Recruit the Exosome to Degrade ARE-containing mRNAs. Cell 107:451-464.

- Park, J.M., Greten, F.R., Li, Z-W., and Karin, M. (2002) Macrophage Apoptosis by Anthrax Lethal Factor and p38 Kinase Inhibition. Science 297:2048-51.

- Hirosumi, J., Tuncman, G., Chang, L., Gorgun, C.Z., Uysal, K.T., Maeda, K., Karin, M. and Hotamisligil, G. A. (2002) Central role for JNK1 in obesity and insulin resistance. Nature 420:333-336.

- Kato, T., Delhase, M., Hoffmann, A. and Karin, M. (2003) CK2 is a C-terminal IkB Kinase Responsible for NF-kB activation during the UV response. Mol. Cell 12:829-839.

- Maeda, S., Chang, L., Li, Z-W, Luo, J-L, Leffert, H. and Karin, M. (2003) IKKb is required for prevention of apoptosis mediated by cell-bound but not by circulating TNFa. Immunity 19:725-737.

- Hsu, L-C, Park, J.M., Zhang, K., Luo, J-L, Maeda, S., Kaufman, R. J., Eckmann, L., Guiney, D. G. and Karin, M. (2004) The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4.  Nature. 428: 341-345.

- Greten, F.R., Eckmann, L., Greten, T.F., Park, J.M., Li, Z-W, Egan, L.J., Kagnoff, M.F. and Karin, M.(2004) IKKb links inflammation and tumorigenesis in a mouse model of colitis associated cancer.  Cell 118:285-296.

- Gao, M., Labuda, T., Xia, Y., Gallagher, E. Fang, D., Liu, Y-C. and Karin, M. (2004) Jun turnover is controlled through JNK-dependent phosphorylation. Science 306:271-275.