Whether it occurs at the organismic, cellular, or molecular level, death always has a negative connotation even though we know everyone must die. Research within the last two decades has lifted the black shroud just a bit, underscoring cell deaths place among the normal physiological processes.

Apoptosis, a term first coined by Andrew H. Wyllie in 1961 for a normal mode of cell death that occurs from boiling within the cells, can be contrasted with the more fearsome mode called necrosis. For hyperproliferative diseases such as cancer, treatments that are successful do not necessarily cause apoptosis. During the last decade several molecular mechanisms that ultimately lead to apoptosis have been outlined. These mechanisms are likely targets of novel treatments for cancer and other hyperproliferative diseases, such as scleroderma, arthritis etc.

This symposium will cover both basic and clinical aspects of apoptosis. The translational aspects of this meeting will bring both clinicians and scientists together to discuss novel means of cancer treatment that exploit apoptotic mechanisms.

We can think of no better place in which to hold this symposium than Kerala because of its unique beauty (it matches Hawaii or any other tropical place), its unique culture (it attracted saints such as St.Thomas), its unique history (which attracted Vasco da Gamma), and its unique place in spirituality (land of Parsuram, yoga, and Ayurveda). One needs to be there to appreciate all these attributes.

Therefore, we would like to welcome all of you to this mysterious land to share your ideas about apoptosis and its role in cancer treatment.